Eczema science explained by the world’s leading experts in every 20 minute episode
Award-nominated podcast featuring a lively monthly dialogue between parents, patients and researchers.
Available on: Spotify, Google Podcasts, and Apple Podcasts.
Listen now! Episodes are listed from newest to oldest below.
Episode 36: Is the gut microbiome the key to allergic diseases?
Could we cure allergies by taking probiotics or transplanting the gut microbiome from a healthy person? What does all this mean for eczema/allergy prevention? To find out, join our conversation with Dr. Rima Rachid, allergist and immunologist at Harvard Children’s Hospital, and Meenal Lele, eczema mom and author of Baby and the Biome. We discuss the promising trials with fecal microbiota transplants for food allergic children as well as the best probiotic to take for eczema and when it’s important to take it. (And if you like our podcast, consider supporting it with a tax deductible donation).
Literature featured in this podcast
Episode 35: Brilliant new ideas for beating eczema from eczema parents
The winners of the 2023 Big Ideas for Eczema contest share their novel ideas and how they came up with them. Our citizen scientist winners are Elizabeth Shores, Hannah Mitchell and Armando de la Libertad. Would you try these ideas? Read more about their ideas here. (If you like our podcast consider supporting it with a tax deductible donation.)
If you have an idea of your own, find out more about the Big Ideas 2024 competition here.
Episode 34: Research Highlights of 2023
Our latest podcast episode highlights some of the top research discoveries of 2023 related to eczema. Tune in to learn about new needle-free Epi-Pen alternatives, painless tests for detecting eczema before it appears, and insights about how to address anxiety and depression related to eczema. Guests include Albert Chong of University of Southern California, Dr. Ruchi Gupta of Northwestern University, Dr. Ian Myles of NIH, and Dr. Kiwako Yamamoto-Hanada of National Children's Hospital, Tokyo.. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this episode
Patients' and Caregivers' Preferences for Mental Health Care and Support in Atopic Dermatitis
Innovations in the treatment of anaphylaxis: A review of recent data
mRNAs in skin surface lipids unveiled atopic dermatitis at 1 month
Episode 33: What’s hot in eczema prevention?
Can moisturizers help prevent eczema? If so: when, what and how should they be applied? Can probiotics help? If so: who should take them - mother or baby? These questions and more are answered by Helen Brough, pediatric allergist and head of service at Evelina London Children's Hospital (UK). As part of our recent research symposium, she explains what research is going on in eczema management and prevention and what is still needed to make prevention a reality. She also has important tips for eczema care now. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this episode
Skin care interventions in infants for preventing eczema and food allergy
Early intervention and prevention of allergic diseases
Emollients in infancy to prevent atopic dermatitis: a systematic review and meta‐analysis
Episode 32: The inflammation-microbiome connection and how new therapies can correct both.
Biological therapies like dupilumab target type 2 inflammation, now new research shows they also modify the skin microbiome. In this episode we discuss what type 2 inflammation is, why it matters in eczema, and how these therapies modify the skin microbiome with Dr. Lisa Beck, Co-Director, Center for Allergic Disease Research, University of Rochester Medical Center, NY. (If you like our podcast consider supporting it with a tax deductible donation.) Check out the transcript here.
Research associated with this podcast:
Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis
Rapid Reduction in Staphylococcus aureus in Atopic Dermatitis Subjects Following Dupilumab Treatment
Episode 31: Is Dupixent forever? Is tapering Dupixent desirable or even possible?
Dupixent (also known as dupilumab) has transformed the lives of people with moderate to severe eczema, but will patients need to use it indefinitely? In this episode we explore tapering Dupixent with two researchers from University Medical Center Utrecht in the Netherlands that have created a patient-led roadmap for successful tapering. They are: Pediatric Dermatologist Dr. Marlies de Graaf, Head of the National Expertise Center of Atopic Dermatitis in Children; and Dr. Celeste Boesjes, who is a PhD candidate and Medical Doctor. (If you like our podcast consider supporting it with a tax deductible donation.) Check out the transcript here.
Research discussed in this podcast:
Episode 30: Ditching itch: What we know and what we still have to learn
Itch. It’s the hallmark symptom of eczema and the most troublesome. In this podcast we discuss why the eczema itch is so hard to treat and explore effective treatment options. We have the privilege of speaking with Dr. Shawn Kwatra, international leader in chronic itch research and Director of John Hopkins Itch Center in Baltimore, and Dr. Shivani Patel, a practicing pediatric dermatologist who specializes in treating children with eczema. (If you like our podcast consider supporting it with a tax deductible donation.) Or check out the transcript.
Research discussed in this podcast:
Cumulative Use of Strong Anticholinergics and Incident Dementia
Episode 29: Exposures to chemicals in our environment and the allergy / eczema epidemic
What do microplastics, dishwasher rinse-aid, air pollution and processed foods have to do with eczema? Join us as we explore why allergic diseases were rare for our grandparents but now affect two billion people worldwide. Explaining the link is our guest, Professor Cezmi Akdis. He is a global leader in immunology, specializing in allergic diseases, editor-in-chief of Allergy, and a Professor at the University of Zurich in Switzerland. (If you like our podcast consider supporting it with a tax deductible donation.) Read the transcript.
Research discussed in this podcast:
Scrubbing away our collective health
Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
The Baby and the Biome (Avery, 2022).
Episode 28: Was it something I did? Does the eczema trajectory begin even before a baby is born?
Have you ever wondered if there is anything you can do during pregnancy to lower the chance of your baby developing eczema? Join our discussion with Dr. Suzanne Barshow from Stanford University who is overseeing the SUNBEAM study which investigates which factors lead to the development of allergic diseases, and Kortney Kwong Hing, co-host of The Itch Podcast and eczema sufferer who would like to avoid passing on her allergies to her future children. (If you like our podcast consider supporting it with a tax deductible donation.) View the transcript.Research discussed in this podcast:
Effect of prenatal dog exposure on eczema development in early and late childhood
Do Probiotics in Pregnancy Reduce Allergies and Asthma in Infancy and Childhood? A Systematic Review
Association of early life exposure to antibiotics with risk of atopic dermatitis in Sweden
Episode 27: Meet the "citizen scientist" winners of our Big Ideas for Eczema Challenge
In our very first “Big Ideas” competition, we asked those who live with eczema for big ideas that could lead to better treatments or a cure. Learn about three brilliant ideas from the winners to help kids with eczema in the future. Our guests are Armando de la Libertad, Nic Novak and Angela Tiru, parents and patients who used their experiences and insights to come up with innovative research ideas. (If you like our podcast consider supporting it with a tax deductible donation.) View the transcript.
Have a Big Idea of your own? Enter this year’s Big Ideas competition here.
Episode 26: Embracing your allergies: how micro-exposures to an allergen can make eczema better.
Could allergy drops (or shots) be the answer to reducing eczema flares? More and more research suggests that immunotherapy can improve eczema symptoms. Immunotherapy is safe for kids, easy to use and cheap. We discuss how the treatment works and it’s potential to improve lives, especially for kids who can’t access expensive treatment programs. Our guests are Dr. Derek Chu, a clinician scientist from McMaster University in Canada, and Dr. Sarah Langer, a pediatric immunologist from the University of Sao Paulo, Brazil. (P.S. If you like our podcast consider supporting it with a tax deductible donation). Read the transcript.
Research discussed in this podcast:
Episode 25: Is eczema inevitable for some kids? Breakthrough research suggests that testing and intervention for newborns could change the trajectory.
Imagine if doctors could use a non-invasive test on newborns to predict their risk of developing eczema? Now it might be possible. What’s more, new research suggests there is something you can do for high risk babies. Join us as we learn about an innovative test for eczema and what you might do with this information. Our guest speakers are Dr. Anne-Sofie Halling who is completing a PhD on biomarkers of atopic dermatitis at Copenhagen University, Denmark; Prof. Alan Irvine a professor of dermatology at Trinity College, Dublin Ireland; and, Prof. Jonathan Hourihane a professor of pediatrics and child health at Royal College of Surgeons in Ireland. (If you like our podcast consider supporting it with a tax deductible donation.) Read the Transcript.
Research discussed in this podcast:
Skin biomarkers predict development of atopic dermatitis in infancy
Skin care interventions in infants for preventing eczema and food allergy
Preventing Atopic Dermatitis and ALLergies in Children-the PreventADALL study.
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial
Episode 24: Is it in your head? How to recognize and address the mental health impacts of eczema
Until recently, the mental health impacts of eczema were hidden and under recognized. However, there's been a spate of new research that shows an association between eczema and mental health conditions like anxiety and depression. And those impacts extend to parents and caregivers as well. Join the discussion with Dr. Mohammad Jafferany, Professor of Psychodermatology Psychiatry and Behavioral Sciences at Central Michigan University; Prof. Andrew Thompson, Professor of Clinical Psychology Cardiff University in the UK; and Dr. Katrina Abuabara, Associate Professor at University of California, San Francisco. A special thank you to Incyte, a member of GPER's Corporate Council, for support of our programs, including the Eczema Breakthroughs Podcast. Read the transcript.
Predictors and age-dependent pattern of psychologic problems in childhood atopic dermatitis
Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort
Effects of family constellation seminars on itch in patients with atopic dermatitis and psoriasis
Mindful parenting intervention for parents of children with skin conditions
Episode 23: Pollution to pollen, floods to fires: how does climate change affect children with sensitive skin?
Our skin protects us from our environment, and global warming is changing that environment. In turn, new research suggests our changing environment can alter our skin. In this episode we explore the impact climate change has on children with eczema and allergies. Our guests are: Dr. Mary Prunicki, Director of Air Pollution and Health Research at the Sean N Parker Centre for Allergy and Asthma Research, Stanford University; Dr. Marc Rothenberg, Director of Allergy and Immunology at Cincinnati Children’s Hospital; Dr. April Schachtel, chief of dermatology for the VA Puget Sound healthcare system in Washington State; and Dr. Markus Boos, pediatric dermatologist at Seattle Children's Hospital. (Please consider supporting our podcast, with a tax deductible donation). If you are interested in this topic, check out our 2022 research symposium highlights. Read the transcript.
Research mentioned:
Climate change and pediatric skin health
Linking the allergy epidemic to climate change
The Air We Breathe: How Extreme Weather Conditions Harm Us
Climate change, the cutaneous microbiome and skin disease: implications for a warming world
Episode 22: Topical Steroids: Game changer or double-edged sword? What does the research say?
Topical corticosteroids use is controversial in our community and generates a lot of concern among caregivers. Yet, it is the mainstay of eczema treatment for children and nearly every child who sees a doctor for eczema is likely using topical steroids. It can help eczema symptoms, but it can be hard to wean off them and then there are side effects. In the first segment, we talk with dermatologist Dr. Steven Feldman from Wake Forest Baptist in North Carolina and two eczema parents who had very different experiences with topical corticosteroids. In the second segment, we discuss the very latest findings on steroid use with UK dermatology nurse Sandra Lawton who is a contributing author on the 2022 Cochrane Review, "What is the best way to use topical corticosteroids to treat people with eczema". (Please consider supporting our podcast, with a tax deductible donation).
Research related to this episode:
What is the best way to use topical corticosteroids to treat people with eczema?
Combined antibiotic, steroid and moisturizer for atopic dermatitis
Topical steroid withdrawal reactions: a review of the evidence
Episode 21: Do we dare dream of a future where eczema and food allergies can be prevented?
Eczema and food allergy are closely intertwined, particularly when it comes to questions of prevention. We know that eczema tends to be the first condition to emerge in the atopic march and there is growing evidence that controlling eczema may actually prevent some of these downstream conditions. Likewise, if we can learn how to prevent eczema so that it never develops in the first place, we may be able to prevent all of the conditions in the atopic march: food allergies, asthma and allergic rhinitis. Find out more on this episode, hosted in partnership with the Food Allergy Fund 2022 Summit, with guests Dr. Peck Ong from Keck School of Medicine, Dr. Aikaterini Anagnostou from Baylor College of Medicine, and Dr. Jessica Hui from National Jewish Health as we delve into how to prevent atopic conditions, starting with eczema. PS. If you like our podcast, consider supporting it with a tax deductible donation.
Episode 20: Are all moisturizers for eczema created equal? The answer appears to be no!
Are certain types of moisturizers better than others for eczema? What is the best way to apply it? In this episode we ask our guest speakers, both researchers who have studied this topic, to weigh in: Dr. Tina Sindher, Clinical Associate Professor of Pediatrics from the Allergy and Clinical Immunology group at Stanford University and Dr. Ian Myles head of the Epithelial Therapeutics Unit at the National Institute of Allergy and Infectious Disease. P.S. If you like our podcast consider supporting it with a tax deductible donation.
Research mentioned in this episode:
Pilot study on trilipid cream versus paraffin-based emollient
The effects of common topical exposures on skin bacteria associated with eczema
Frequent moisturizer use in infancy and later development of food allergy
Episode 19: Let’s get real: Why are eczema patients struggling worldwide?
Globally, patients and caregivers are often left to figure out the daunting task of getting eczema under control by medical systems that provide limited direction. In a first-of-its kind collaboration between patient organizations from eight countries coordinated by Global Parents for Eczema Research, we reveal the results of a 3,200 response survey which show how eczema patients are faring and to what extent medical care and treatments are meeting their needs. Our guests are Rachael Manion from the Canadian Skin Patient Alliance, Andrew Proctor from the National Eczema Society in the United Kingdom and Cheryl Talent from the Eczema Association of Australasia.
(If you like our podcast consider supporting it with a tax deductible donation.)
Research referred to in this podcast:
Global Patient Initiative to Improve Eczema Care (https://www.improveeczemacare.com/)
Episode 18: A new menu of options for eczema: A first look at just-approved treatments
In the last few months, a record FOUR new treatments have been approved for eczema in the United States, with other countries considering approval as well. At long last, kids with moderate-to-severe eczema will soon have new, effective options. What are these new treatments, their side effects and what do parents need to know about safety? Tune in as we discuss these emerging treatments with our expert guest speakers: Dr. Amy Paller, Professor of Pediatrics and Chair of the Department of Dermatology at Northwestern University, Chicago; and Dr. Aaron Drucker, Assistant Professor and Dermatologist at the University of Toronto, Canada. (P.S. If you like our podcast consider supporting it with a tax deductible donation).
Research & resources relevant to this podcast:
Novel treatments for pediatric atopic dermatitis.
Episode 17: Where do you turn to when you’re at the end of your rope? Mentorship and support for eczema parents
Studies by Global Parents for Eczema Research have shed light on the many mental health, quality of life, and life course impacts experienced by parents who care for children with moderate to severe eczema. The impacts are often hidden from view and take an enormous toll on caregivers who have the daunting challenge of controlling and managing eczema at all hours of the day and night, often without a break. Healthcare systems usually aren’t set up to address the needs of parents of children with serious medical issues. As a result, parents and caregivers are on their own, stressed, isolated, and without support. In this episode we discuss this common experience with several parents who are part of GPER’s Support for Eczema Caregivers Program, which was launched in 2020 to provide mentoring and listening support to parents and caregivers struggling with the many hidden challenges of living with eczema. For more about this program go to: www.parentsforeczemaresearch.com/caregiver
Research in this episode:
Impact of Childhood Atopic Dermatitis on Life Decisions for Caregivers and Families
Episode 16: The surprising relationship between COVID risk & eczema
At the beginning of the pandemic, the prevailing theory was that people with eczema would be at higher risk for COVID-19 infection and severe symptoms because they were taking treatments that suppress the immune system or because they also had asthma which was thought to complicate symptoms. But, in a rare bit of good news, research is suggesting the exact opposite may be true. Tune in to learn how the immune system abnormalities associated with eczema may actually protect against COVID-19 infection and how one treatment may reduce the risk of severe symptoms after infection. Our guests are Dr. Emma Guttman-Yassky, Professor of Dermatology and Immunology at the Icahn School of Medicine at Mount Sinai; Dr. Benjamin Ungar Assistant Professor of Dermatology also at Mount Sinai; and Dr. Adrian Martineau Professor of Respiratory Infection and Immunity Sciences in the School of Medicine at Queen Mary University of London.
Research referenced in this episode:
Episode 15: To bathe or not to bathe, that is the question!
Many parents receive conflicting advice about how and how often to bathe a child with eczema, which leads to confusion around this common ritual. On the one hand, baths can quell itch, and hydrate the skin prior to moisturization; on the other, over-bathing may actually dry out the skin and compromise the skin barrier. In this episode, we delve into the research on bathing and eczema with special guest Dr. Thomas Marrs, a pediatric allergist at St Thomas Hospital in the United Kingdom. Dr. Marrs studies how the microbiome influences the development of allergic diseases. P.S. If you like our podcast, consider making a tax-deductible donation to Global Parents for Eczema Research to help us continue to produce quality shows in 2022. And a special thank you to Sanofi Genzyme and Regeneron and our individual donors for supporting Eczema Breakthroughs this year!
Research referenced in this episode:
Bathing Babies More Than Once a Week Ups Eczema Risk
Frequent Versus Infrequent Bathing in Pediatric Atopic Dermatitis: A Randomized Clinical Trial
Episode 14: Passing the baton on eczema care from parent to child
When children are young, parents have to manage their eczema care, and it’s a role that usually lasts a decade or more. But when children reach adolescence, parents must hand over the reins and learn to let go. In this episode we explore some pitfalls with this sometimes-tumultuous period as well as tips and best practices for navigating it with patience and skill. We examine the issues from the perspectives of both parents and young people. Our guest, Dr. Miriam Santer, studies this topic at University of Southampton. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research mentioned in this episode:
Children’s views and experiences of treatment adherence and parent/child co-management in eczem
Taking charge of eczema self-management: a qualitative interview study with young people with eczema
Episode 13: Follow your gut! Can fecal microbiota transplants (FMT) be used to treat, or even cure, eczema?
In this episode we explore the promise of an emerging therapy for inflammatory conditions like eczema: transplanting the fecal matter of a healthy person into the gut of a person with eczema. It sounds far-fetched (and even a little off-putting!) but this therapy has actually been around for 2000 years and was first used in ancient China to treat infections. More recently, FMT has been shown to cure difficult-to-treat intestinal infection and is emerging as a promising approach for a range of immune system related conditions (including eczema). Our guest is Dr. Siew Ng, a fecal microbiota transplant researcher with the Chinese University of Hong Kong. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research mentioned in this episode:
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy
Episode 12: Feed Babies Peanuts? The latest science on the intersection of eczema and food allergies
Parents of children with eczema often end up on a long journey to determine what triggers their child’s flares, and food is often suspected to be a culprit. But restricting food too early can confuse the immune system and create problems later on. In this episode, co-hosted with Susan Weissman of the Food Allergy Fund (FAF) and produced as part of the FAF Annual Summit, we ask our panel of experts how and when to introduce foods like nuts, dairy, eggs, and wheat in children with eczema and what the implications are for the development of food allergy. Our panelists include Dr. Michael Pistiner, Director of Food Allergy Advocacy, Education and Prevention at Massachusetts General Hospital and Dr. Corinne Keet, professor of pediatrics at Johns Hopkins University. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research referenced in this episode:
The Sunbeam Study on Early Predictors, Mechanisms of Food Allergy and Eczema
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
Find the transcript here!
Episode 11: Learning Disability and Eczema
New research suggests a link between eczema and learning disabilities in children. But how can we tease out the effect of itch, sleep, treatment and other factors to know if the learning disability is real? Join us for this enlightening discussion with Dr. Joy Wan, dermatologist and researcher with Children’s Hospital of Philadelphia and lead author on a recently published study that looked at this complicated relationship (see link below). Find the transcript here.
Research referenced in this episode:
Association of Atopic Dermatitis Severity With Learning Disability in Children
Episode 10. The Evolving Medicine Cabinet: What do we know about steroid creams and ointments? Plus a look at new “topical” medications on the horizon!
In this episode we talk about parents’ concerns with topical steroids and what we do and don’t know about the risks and benefits of using this mainstay of treatment. We also explore NEW topical treatments for eczema that may be safer to use long term. Our guest is Dr. Elaine Siegfried, Director of the Division of Pediatric Dermatology At Saint Louis University and Cardinal Glennon Children’s Hospital and our co-host is parent Angela Tiru. Join us for a deep dive into all the controversial questions and more. You can find the transcript here.
Research referenced in this episode:
Long-term safety of topical corticosteroids and topical calcineurin inhibitors
Episode 9: Food allergies and eczema … it takes two to tango!
In this episode we explore the bi-directional relationship between food allergies and eczema with two leading pediatric allergists. Our guests are Dr. Anne Marie Singh, an allergy and immunology specialist with a focus in pediatrics with the University of Wisconsin School of Medicine and Public Health, and Dr. Peck Ong, Associate Professor of Clinical Pediatrics at the University of Southern California and attending physician in the Division of Clinical Immunology and Allergy at Children’s Hospital in Los Angeles. Our conversation explores how and when food allergies can trigger eczema as well as how eczema can serve as the gateway to food allergies; new approaches to treating food allergy; and future directions for preventing both conditions.
Research referenced in this episode:
Controversies in allergy: food testing and dietary avoidance in atopic dermatitis
Scratching the skin primes the gut for allergic reactions to food
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 8: Defining Eczema Types and Preparing for the Precision Medicine Revolution
How close are we to targeted treatments designed to each person with eczema? As parents, we often hear from people about a miracle approach that “cured” their or their child’s eczema, only to find that this same approach doesn’t work for us. We are continually reminded of the many different ways that eczema can appear and feel, and how people respond differently to different treatments. Right now, we have a largely “trial and error” approach to treating eczema but what will the future look like as we begin to understand eczema variation, sub-types, and personalized medicine? In this episode of the Eczema Breakthroughs podcast we chat with Professor Thomas Bieber who is chair and director of the department of dermatology and allergy at the University of Bonn in Germany. His cutting edge research focuses on biomarker discovery and precision medicine in allergic skin diseases and he was a speaker on the topic of risk stratification at the recent Revolutionizing Atopic Dermatitis global conference in April.
Research referenced in this episode:
Eczema types: Where are we and where should we go?
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 7: Tales from the Frontlines
In this episode, six parents of children with eczema from around the world share common experiences, challenges and silver linings from their eczema journeys, and dispel myths and misperceptions about the condition. Join us for this special edition of Eczema Breakthroughs recorded for World Atopic Eczema Day (#atopiceczemaday), which takes place annually on September 14th. Episode 7 is co-hosted with Keri Kelley.
Episode 6: What do the Iditarod and the immune system have in common? How can we harness the body’s defenses for fighting off infections and invaders to tackle eczema and its complications, including eczema herpeticum. Our guest for this episode of Eczema Breakthroughs is Dr. Brian Kim, Associate Professor of Medicine and Co-Director of the Center for the Study of Itch and Sensory Disorders at Washington University School of Medicine in St. Louis. His laboratory focuses on the immune mechanisms that underlie skin inflammation and the sensation of itch, and his groundbreaking translational research is showing new ways for addressing eczema by priming – rather than discouraging – the immune system. Episode 6 is co-hosted with Angela Tiru.
Research referenced in this episode:
Episode 5: Dispatches from the frontlines of the "Battle of the Bacteria" with Dr. Richard Gallo
There’s a battle underway on the skin between bacteria that make eczema worse and bacteria that can improve symptoms. This fascinating discussion with Dr. Richard Gallo, Chairman of the Department of Dermatology at the University of California-San Diego, highlights his ground-breaking research approach which amplifies the presence of “good” bacteria in order to control domination of problematic strains, like Staph aureus. This bacterial "tinkering" is showing great promise against eczema. This podcast was recorded in 2018 as part of GPER’s research meetup series.
Research referenced in this podcast:
Eczema-associated bacteria may be kept in check by a different microbe
The microbiome in patients with atopic dermatitis
Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Episode 4: A Roadmap for Navigating the New Eczema Treatment Landscape with Dr. Eric Simpson
Almost every week we hear about new treatments for eczema, many with names that are hard to pronounce and even harder to remember. After a long drought, we’re suddenly experiencing a downpour in new options, but for parents and patients, it’s hard to navigate this evolving landscape. Dr. Eric Simpson, a dermatologist with OHSU and leading expert on new eczema treatments, walks us through what’s new, what’s coming, and how to make sense of it all.
Research referenced in this podcast:
Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis
Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis
Therapeutic Pipeline for Atopic Dermatitis: End of the Drought?
This podcast episode was co-hosted by the Pediatric Dermatology Research Alliance (PeDRA), and produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 3: A critical look at common treatment practices with Dr. Jonathan Silverberg
Oral and systemic steroids are used to treat eczema all the time, but are they safe and do they make sense for a long-term chronic disease? Antihistamines are the most commonly prescribed oral treatment for eczema, but do they actually address its symptoms and what are the risks of use in children? Dr. Jonathan Silverberg, a dermatologist and researcher with George Washington University, offers some straight talk in this episode of Eczema Breakthroughs. Tune in!
Research referenced in this podcast:
Comorbidities and the impact of atopic dermatitis
Use of systemic corticosteroids for atopic dermatitis
Increased ADHD symptoms in atopic dermatitis are associated with antihistamine use
A systemic review of the safety and efficacy of systemic steroids
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis (RAD) Conference and with support from Sanofi Genzyme and Regeneron.
Episode 2: Messing with the Microbiome. A Conversation with Dr. Ian Myles
Why is eczema prevalence on the rise? Are chemicals found in many skin and cosmetic products to blame? How do we restore a healthy balance of bacteria on eczema-prone skin? Is eczema a genetic disease or is that a myth? Learn more by listening to this provocative chat with Dr. Ian Myles, a cutting-edge researcher with the NIH who studies "microbiome transplants" for the treatment of eczema.
Research referenced in this podcast:
First in-human microbiome transplant using Roseomonas mucosa bacteria
Is allergy a disease of dysbiosis?
Episode 1: New ideas and ancient science -- A conversation with Dr. Peter Lio
Can you control itch with acupressure? Can toxins from bacteria complicate eczema? What is the Dr. Aron Regimen and what are we learning about it through research? Learn more in this interview with Dr. Peter Lio, a dermatologist and researcher with Northwestern University and the Chicago Integrative Eczema Center.
Research referenced in this podcast:
Acupressure Study
Review of alternative and complementary treatments for eczema
Case series study on CASM (Dr. Aron Regimen)
Review of the relationship between staph and eczema
Episode 33: What’s hot in eczema prevention?
Can moisturizers help prevent eczema? If so: when, what and how should they be applied? Can probiotics help? If so: who should take them - mother or baby? These questions and more are answered by Helen Brough, pediatric allergist and head of service at Evelina London Children's Hospital (UK). As part of our recent research symposium, she explains what research is going on in eczema management and prevention and what is still needed to make prevention a reality. She also has important tips for eczema care now. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this episode
Skin care interventions in infants for preventing eczema and food allergy
Early intervention and prevention of allergic diseases
Emollients in infancy to prevent atopic dermatitis: a systematic review and meta‐analysis
Episode 32: The inflammation-microbiome connection and how new therapies can correct both.
Biological therapies like dupilumab target type 2 inflammation, now new research shows they also modify the skin microbiome. In this episode we discuss what type 2 inflammation is, why it matters in eczema, and how these therapies modify the skin microbiome with Dr. Lisa Beck, Co-Director, Center for Allergic Disease Research, University of Rochester Medical Center, NY. (If you like our podcast consider supporting it with a tax deductible donation.) Check out the transcript here.
Research associated with this podcast:
Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis
Rapid Reduction in Staphylococcus aureus in Atopic Dermatitis Subjects Following Dupilumab Treatment
Episode 31: Is Dupixent forever? Is tapering Dupixent desirable or even possible?
Dupixent (also known as dupilumab) has transformed the lives of people with moderate to severe eczema, but will patients need to use it indefinitely? In this episode we explore tapering Dupixent with two researchers from University Medical Center Utrecht in the Netherlands that have created a patient-led roadmap for successful tapering. They are: Pediatric Dermatologist Dr. Marlies de Graaf, Head of the National Expertise Center of Atopic Dermatitis in Children; and Dr. Celeste Boesjes, who is a PhD candidate and Medical Doctor. (If you like our podcast consider supporting it with a tax deductible donation.) Check out the transcript here.
Research discussed in this podcast:
Episode 30: Ditching itch: What we know and what we still have to learn
Itch. It’s the hallmark symptom of eczema and the most troublesome. In this podcast we discuss why the eczema itch is so hard to treat and explore effective treatment options. We have the privilege of speaking with Dr. Shawn Kwatra, international leader in chronic itch research and Director of John Hopkins Itch Center in Baltimore, and Dr. Shivani Patel, a practicing pediatric dermatologist who specializes in treating children with eczema. (If you like our podcast consider supporting it with a tax deductible donation.) Or check out the transcript.
Research discussed in this podcast:
Cumulative Use of Strong Anticholinergics and Incident Dementia
Episode 29: Exposures to chemicals in our environment and the allergy / eczema epidemic
What do microplastics, dishwasher rinse-aid, air pollution and processed foods have to do with eczema? Join us as we explore why allergic diseases were rare for our grandparents but now affect two billion people worldwide. Explaining the link is our guest, Professor Cezmi Akdis. He is a global leader in immunology, specializing in allergic diseases, editor-in-chief of Allergy, and a Professor at the University of Zurich in Switzerland. (If you like our podcast consider supporting it with a tax deductible donation.) Read the transcript.
Research discussed in this podcast:
Scrubbing away our collective health
Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
The Baby and the Biome (Avery, 2022).
Episode 28: Was it something I did? Does the eczema trajectory begin even before a baby is born?
Have you ever wondered if there is anything you can do during pregnancy to lower the chance of your baby developing eczema? Join our discussion with Dr. Suzanne Barshow from Stanford University who is overseeing the SUNBEAM study which investigates which factors lead to the development of allergic diseases, and Kortney Kwong Hing, co-host of The Itch Podcast and eczema sufferer who would like to avoid passing on her allergies to her future children. (If you like our podcast consider supporting it with a tax deductible donation.) View the transcript.Research discussed in this podcast:
Effect of prenatal dog exposure on eczema development in early and late childhood
Do Probiotics in Pregnancy Reduce Allergies and Asthma in Infancy and Childhood? A Systematic Review
Association of early life exposure to antibiotics with risk of atopic dermatitis in Sweden
Episode 27: Meet the "citizen scientist" winners of our Big Ideas for Eczema Challenge
In our very first “Big Ideas” competition, we asked those who live with eczema for big ideas that could lead to better treatments or a cure. Learn about three brilliant ideas from the winners to help kids with eczema in the future. Our guests are Armando de la Libertad, Nic Novak and Angela Tiru, parents and patients who used their experiences and insights to come up with innovative research ideas. (If you like our podcast consider supporting it with a tax deductible donation.) View the transcript.
Have a Big Idea of your own? Enter this year’s Big Ideas competition here.
Episode 26: Embracing your allergies: how micro-exposures to an allergen can make eczema better.
Could allergy drops (or shots) be the answer to reducing eczema flares? More and more research suggests that immunotherapy can improve eczema symptoms. Immunotherapy is safe for kids, easy to use and cheap. We discuss how the treatment works and it’s potential to improve lives, especially for kids who can’t access expensive treatment programs. Our guests are Dr. Derek Chu, a clinician scientist from McMaster University in Canada, and Dr. Sarah Langer, a pediatric immunologist from the University of Sao Paulo, Brazil. (P.S. If you like our podcast consider supporting it with a tax deductible donation). Read the transcript.
Research discussed in this podcast:
Episode 25: Is eczema inevitable for some kids? Breakthrough research suggests that testing and intervention for newborns could change the trajectory.
Imagine if doctors could use a non-invasive test on newborns to predict their risk of developing eczema? Now it might be possible. What’s more, new research suggests there is something you can do for high risk babies. Join us as we learn about an innovative test for eczema and what you might do with this information. Our guest speakers are Dr. Anne-Sofie Halling who is completing a PhD on biomarkers of atopic dermatitis at Copenhagen University, Denmark; Prof. Alan Irvine a professor of dermatology at Trinity College, Dublin Ireland; and, Prof. Jonathan Hourihane a professor of pediatrics and child health at Royal College of Surgeons in Ireland. (If you like our podcast consider supporting it with a tax deductible donation.) Read the Transcript.
Research discussed in this podcast:
Skin biomarkers predict development of atopic dermatitis in infancy
Skin care interventions in infants for preventing eczema and food allergy
Preventing Atopic Dermatitis and ALLergies in Children-the PreventADALL study.
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial
Episode 24: Is it in your head? How to recognize and address the mental health impacts of eczema
Until recently, the mental health impacts of eczema were hidden and under recognized. However, there's been a spate of new research that shows an association between eczema and mental health conditions like anxiety and depression. And those impacts extend to parents and caregivers as well. Join the discussion with Dr. Mohammad Jafferany, Professor of Psychodermatology Psychiatry and Behavioral Sciences at Central Michigan University; Prof. Andrew Thompson, Professor of Clinical Psychology Cardiff University in the UK; and Dr. Katrina Abuabara, Associate Professor at University of California, San Francisco. A special thank you to Incyte, a member of GPER's Corporate Council, for support of our programs, including the Eczema Breakthroughs Podcast. Read the transcript.
Predictors and age-dependent pattern of psychologic problems in childhood atopic dermatitis
Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort
Effects of family constellation seminars on itch in patients with atopic dermatitis and psoriasis
Mindful parenting intervention for parents of children with skin conditions
Episode 23: Pollution to pollen, floods to fires: how does climate change affect children with sensitive skin?
Our skin protects us from our environment, and global warming is changing that environment. In turn, new research suggests our changing environment can alter our skin. In this episode we explore the impact climate change has on children with eczema and allergies. Our guests are: Dr. Mary Prunicki, Director of Air Pollution and Health Research at the Sean N Parker Centre for Allergy and Asthma Research, Stanford University; Dr. Marc Rothenberg, Director of Allergy and Immunology at Cincinnati Children’s Hospital; Dr. April Schachtel, chief of dermatology for the VA Puget Sound healthcare system in Washington State; and Dr. Markus Boos, pediatric dermatologist at Seattle Children's Hospital. (Please consider supporting our podcast, with a tax deductible donation). If you are interested in this topic, check out our 2022 research symposium highlights. Read the transcript.
Research mentioned:
Climate change and pediatric skin health
Linking the allergy epidemic to climate change
The Air We Breathe: How Extreme Weather Conditions Harm Us
Climate change, the cutaneous microbiome and skin disease: implications for a warming world
Episode 22: Topical Steroids: Game changer or double-edged sword? What does the research say?
Topical corticosteroids use is controversial in our community and generates a lot of concern among caregivers. Yet, it is the mainstay of eczema treatment for children and nearly every child who sees a doctor for eczema is likely using topical steroids. It can help eczema symptoms, but it can be hard to wean off them and then there are side effects. In the first segment, we talk with dermatologist Dr. Steven Feldman from Wake Forest Baptist in North Carolina and two eczema parents who had very different experiences with topical corticosteroids. In the second segment, we discuss the very latest findings on steroid use with UK dermatology nurse Sandra Lawton who is a contributing author on the 2022 Cochrane Review, "What is the best way to use topical corticosteroids to treat people with eczema". (Please consider supporting our podcast, with a tax deductible donation).
Research related to this episode:
What is the best way to use topical corticosteroids to treat people with eczema?
Combined antibiotic, steroid and moisturizer for atopic dermatitis
Topical steroid withdrawal reactions: a review of the evidence
Episode 21: Do we dare dream of a future where eczema and food allergies can be prevented?
Eczema and food allergy are closely intertwined, particularly when it comes to questions of prevention. We know that eczema tends to be the first condition to emerge in the atopic march and there is growing evidence that controlling eczema may actually prevent some of these downstream conditions. Likewise, if we can learn how to prevent eczema so that it never develops in the first place, we may be able to prevent all of the conditions in the atopic march: food allergies, asthma and allergic rhinitis. Find out more on this episode, hosted in partnership with the Food Allergy Fund 2022 Summit, with guests Dr. Peck Ong from Keck School of Medicine, Dr. Aikaterini Anagnostou from Baylor College of Medicine, and Dr. Jessica Hui from National Jewish Health as we delve into how to prevent atopic conditions, starting with eczema. PS. If you like our podcast, consider supporting it with a tax deductible donation.
Episode 20: Are all moisturizers for eczema created equal? The answer appears to be no!
Are certain types of moisturizers better than others for eczema? What is the best way to apply it? In this episode we ask our guest speakers, both researchers who have studied this topic, to weigh in: Dr. Tina Sindher, Clinical Associate Professor of Pediatrics from the Allergy and Clinical Immunology group at Stanford University and Dr. Ian Myles head of the Epithelial Therapeutics Unit at the National Institute of Allergy and Infectious Disease. P.S. If you like our podcast consider supporting it with a tax deductible donation.
Research mentioned in this episode:
Pilot study on trilipid cream versus paraffin-based emollient
The effects of common topical exposures on skin bacteria associated with eczema
Frequent moisturizer use in infancy and later development of food allergy
Episode 19: Let’s get real: Why are eczema patients struggling worldwide?
Globally, patients and caregivers are often left to figure out the daunting task of getting eczema under control by medical systems that provide limited direction. In a first-of-its kind collaboration between patient organizations from eight countries coordinated by Global Parents for Eczema Research, we reveal the results of a 3,200 response survey which show how eczema patients are faring and to what extent medical care and treatments are meeting their needs. Our guests are Rachael Manion from the Canadian Skin Patient Alliance, Andrew Proctor from the National Eczema Society in the United Kingdom and Cheryl Talent from the Eczema Association of Australasia.
(If you like our podcast consider supporting it with a tax deductible donation.)
Research referred to in this podcast:
Global Patient Initiative to Improve Eczema Care (https://www.improveeczemacare.com/)
Episode 18: A new menu of options for eczema: A first look at just-approved treatments
In the last few months, a record FOUR new treatments have been approved for eczema in the United States, with other countries considering approval as well. At long last, kids with moderate-to-severe eczema will soon have new, effective options. What are these new treatments, their side effects and what do parents need to know about safety? Tune in as we discuss these emerging treatments with our expert guest speakers: Dr. Amy Paller, Professor of Pediatrics and Chair of the Department of Dermatology at Northwestern University, Chicago; and Dr. Aaron Drucker, Assistant Professor and Dermatologist at the University of Toronto, Canada. (P.S. If you like our podcast consider supporting it with a tax deductible donation).
Research & resources relevant to this podcast:
Novel treatments for pediatric atopic dermatitis.
Episode 17: Where do you turn to when you’re at the end of your rope? Mentorship and support for eczema parents
Studies by Global Parents for Eczema Research have shed light on the many mental health, quality of life, and life course impacts experienced by parents who care for children with moderate to severe eczema. The impacts are often hidden from view and take an enormous toll on caregivers who have the daunting challenge of controlling and managing eczema at all hours of the day and night, often without a break. Healthcare systems usually aren’t set up to address the needs of parents of children with serious medical issues. As a result, parents and caregivers are on their own, stressed, isolated, and without support. In this episode we discuss this common experience with several parents who are part of GPER’s Support for Eczema Caregivers Program, which was launched in 2020 to provide mentoring and listening support to parents and caregivers struggling with the many hidden challenges of living with eczema. For more about this program go to: www.parentsforeczemaresearch.com/caregiver
Research in this episode:
Impact of Childhood Atopic Dermatitis on Life Decisions for Caregivers and Families
Episode 16: The surprising relationship between COVID risk & eczema
At the beginning of the pandemic, the prevailing theory was that people with eczema would be at higher risk for COVID-19 infection and severe symptoms because they were taking treatments that suppress the immune system or because they also had asthma which was thought to complicate symptoms. But, in a rare bit of good news, research is suggesting the exact opposite may be true. Tune in to learn how the immune system abnormalities associated with eczema may actually protect against COVID-19 infection and how one treatment may reduce the risk of severe symptoms after infection. Our guests are Dr. Emma Guttman-Yassky, Professor of Dermatology and Immunology at the Icahn School of Medicine at Mount Sinai; Dr. Benjamin Ungar Assistant Professor of Dermatology also at Mount Sinai; and Dr. Adrian Martineau Professor of Respiratory Infection and Immunity Sciences in the School of Medicine at Queen Mary University of London.
Research referenced in this episode:
Episode 15: To bathe or not to bathe, that is the question!
Many parents receive conflicting advice about how and how often to bathe a child with eczema, which leads to confusion around this common ritual. On the one hand, baths can quell itch, and hydrate the skin prior to moisturization; on the other, over-bathing may actually dry out the skin and compromise the skin barrier. In this episode, we delve into the research on bathing and eczema with special guest Dr. Thomas Marrs, a pediatric allergist at St Thomas Hospital in the United Kingdom. Dr. Marrs studies how the microbiome influences the development of allergic diseases. P.S. If you like our podcast, consider making a tax-deductible donation to Global Parents for Eczema Research to help us continue to produce quality shows in 2022. And a special thank you to Sanofi Genzyme and Regeneron and our individual donors for supporting Eczema Breakthroughs this year!
Research referenced in this episode:
Bathing Babies More Than Once a Week Ups Eczema Risk
Frequent Versus Infrequent Bathing in Pediatric Atopic Dermatitis: A Randomized Clinical Trial
Episode 14: Passing the baton on eczema care from parent to child
When children are young, parents have to manage their eczema care, and it’s a role that usually lasts a decade or more. But when children reach adolescence, parents must hand over the reins and learn to let go. In this episode we explore some pitfalls with this sometimes-tumultuous period as well as tips and best practices for navigating it with patience and skill. We examine the issues from the perspectives of both parents and young people. Our guest, Dr. Miriam Santer, studies this topic at University of Southampton. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research mentioned in this episode:
Children’s views and experiences of treatment adherence and parent/child co-management in eczem
Taking charge of eczema self-management: a qualitative interview study with young people with eczema
Episode 13: Follow your gut! Can fecal microbiota transplants (FMT) be used to treat, or even cure, eczema?
In this episode we explore the promise of an emerging therapy for inflammatory conditions like eczema: transplanting the fecal matter of a healthy person into the gut of a person with eczema. It sounds far-fetched (and even a little off-putting!) but this therapy has actually been around for 2000 years and was first used in ancient China to treat infections. More recently, FMT has been shown to cure difficult-to-treat intestinal infection and is emerging as a promising approach for a range of immune system related conditions (including eczema). Our guest is Dr. Siew Ng, a fecal microbiota transplant researcher with the Chinese University of Hong Kong. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research mentioned in this episode:
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy
Episode 12: Feed Babies Peanuts? The latest science on the intersection of eczema and food allergies
Parents of children with eczema often end up on a long journey to determine what triggers their child’s flares, and food is often suspected to be a culprit. But restricting food too early can confuse the immune system and create problems later on. In this episode, co-hosted with Susan Weissman of the Food Allergy Fund (FAF) and produced as part of the FAF Annual Summit, we ask our panel of experts how and when to introduce foods like nuts, dairy, eggs, and wheat in children with eczema and what the implications are for the development of food allergy. Our panelists include Dr. Michael Pistiner, Director of Food Allergy Advocacy, Education and Prevention at Massachusetts General Hospital and Dr. Corinne Keet, professor of pediatrics at Johns Hopkins University. Tune in to the dialogue to learn more! (If you like our podcast consider supporting it with a tax deductible donation.)
Research referenced in this episode:
The Sunbeam Study on Early Predictors, Mechanisms of Food Allergy and Eczema
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
Find the transcript here!
Episode 11: Learning Disability and Eczema
New research suggests a link between eczema and learning disabilities in children. But how can we tease out the effect of itch, sleep, treatment and other factors to know if the learning disability is real? Join us for this enlightening discussion with Dr. Joy Wan, dermatologist and researcher with Children’s Hospital of Philadelphia and lead author on a recently published study that looked at this complicated relationship (see link below). Find the transcript here.
Research referenced in this episode:
Association of Atopic Dermatitis Severity With Learning Disability in Children
Episode 10. The Evolving Medicine Cabinet: What do we know about steroid creams and ointments? Plus a look at new “topical” medications on the horizon!
In this episode we talk about parents’ concerns with topical steroids and what we do and don’t know about the risks and benefits of using this mainstay of treatment. We also explore NEW topical treatments for eczema that may be safer to use long term. Our guest is Dr. Elaine Siegfried, Director of the Division of Pediatric Dermatology At Saint Louis University and Cardinal Glennon Children’s Hospital and our co-host is parent Angela Tiru. Join us for a deep dive into all the controversial questions and more. You can find the transcript here.
Research referenced in this episode:
Long-term safety of topical corticosteroids and topical calcineurin inhibitors
Episode 9: Food allergies and eczema … it takes two to tango!
In this episode we explore the bi-directional relationship between food allergies and eczema with two leading pediatric allergists. Our guests are Dr. Anne Marie Singh, an allergy and immunology specialist with a focus in pediatrics with the University of Wisconsin School of Medicine and Public Health, and Dr. Peck Ong, Associate Professor of Clinical Pediatrics at the University of Southern California and attending physician in the Division of Clinical Immunology and Allergy at Children’s Hospital in Los Angeles. Our conversation explores how and when food allergies can trigger eczema as well as how eczema can serve as the gateway to food allergies; new approaches to treating food allergy; and future directions for preventing both conditions.
Research referenced in this episode:
Controversies in allergy: food testing and dietary avoidance in atopic dermatitis
Scratching the skin primes the gut for allergic reactions to food
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 8: Defining Eczema Types and Preparing for the Precision Medicine Revolution
How close are we to targeted treatments designed to each person with eczema? As parents, we often hear from people about a miracle approach that “cured” their or their child’s eczema, only to find that this same approach doesn’t work for us. We are continually reminded of the many different ways that eczema can appear and feel, and how people respond differently to different treatments. Right now, we have a largely “trial and error” approach to treating eczema but what will the future look like as we begin to understand eczema variation, sub-types, and personalized medicine? In this episode of the Eczema Breakthroughs podcast we chat with Professor Thomas Bieber who is chair and director of the department of dermatology and allergy at the University of Bonn in Germany. His cutting edge research focuses on biomarker discovery and precision medicine in allergic skin diseases and he was a speaker on the topic of risk stratification at the recent Revolutionizing Atopic Dermatitis global conference in April.
Research referenced in this episode:
Eczema types: Where are we and where should we go?
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 7: Tales from the Frontlines
In this episode, six parents of children with eczema from around the world share common experiences, challenges and silver linings from their eczema journeys, and dispel myths and misperceptions about the condition. Join us for this special edition of Eczema Breakthroughs recorded for World Atopic Eczema Day (#atopiceczemaday), which takes place annually on September 14th. Episode 7 is co-hosted with Keri Kelley.
Episode 6: What do the Iditarod and the immune system have in common? How can we harness the body’s defenses for fighting off infections and invaders to tackle eczema and its complications, including eczema herpeticum. Our guest for this episode of Eczema Breakthroughs is Dr. Brian Kim, Associate Professor of Medicine and Co-Director of the Center for the Study of Itch and Sensory Disorders at Washington University School of Medicine in St. Louis. His laboratory focuses on the immune mechanisms that underlie skin inflammation and the sensation of itch, and his groundbreaking translational research is showing new ways for addressing eczema by priming – rather than discouraging – the immune system. Episode 6 is co-hosted with Angela Tiru.
Research referenced in this episode:
Episode 5: Dispatches from the frontlines of the "Battle of the Bacteria" with Dr. Richard Gallo
There’s a battle underway on the skin between bacteria that make eczema worse and bacteria that can improve symptoms. This fascinating discussion with Dr. Richard Gallo, Chairman of the Department of Dermatology at the University of California-San Diego, highlights his ground-breaking research approach which amplifies the presence of “good” bacteria in order to control domination of problematic strains, like Staph aureus. This bacterial "tinkering" is showing great promise against eczema. This podcast was recorded in 2018 as part of GPER’s research meetup series.
Research referenced in this podcast:
Eczema-associated bacteria may be kept in check by a different microbe
The microbiome in patients with atopic dermatitis
Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Episode 4: A Roadmap for Navigating the New Eczema Treatment Landscape with Dr. Eric Simpson
Almost every week we hear about new treatments for eczema, many with names that are hard to pronounce and even harder to remember. After a long drought, we’re suddenly experiencing a downpour in new options, but for parents and patients, it’s hard to navigate this evolving landscape. Dr. Eric Simpson, a dermatologist with OHSU and leading expert on new eczema treatments, walks us through what’s new, what’s coming, and how to make sense of it all.
Research referenced in this podcast:
Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis
Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis
Therapeutic Pipeline for Atopic Dermatitis: End of the Drought?
This podcast episode was co-hosted by the Pediatric Dermatology Research Alliance (PeDRA), and produced in collaboration with the Revolutionizing Atopic Dermatitis Conference with support from Sanofi Genzyme and Regeneron.
Episode 3: A critical look at common treatment practices with Dr. Jonathan Silverberg
Oral and systemic steroids are used to treat eczema all the time, but are they safe and do they make sense for a long-term chronic disease? Antihistamines are the most commonly prescribed oral treatment for eczema, but do they actually address its symptoms and what are the risks of use in children? Dr. Jonathan Silverberg, a dermatologist and researcher with George Washington University, offers some straight talk in this episode of Eczema Breakthroughs. Tune in!
Research referenced in this podcast:
Comorbidities and the impact of atopic dermatitis
Use of systemic corticosteroids for atopic dermatitis
Increased ADHD symptoms in atopic dermatitis are associated with antihistamine use
A systemic review of the safety and efficacy of systemic steroids
This podcast episode was produced in collaboration with the Revolutionizing Atopic Dermatitis (RAD) Conference and with support from Sanofi Genzyme and Regeneron.
Episode 2: Messing with the Microbiome. A Conversation with Dr. Ian Myles
Why is eczema prevalence on the rise? Are chemicals found in many skin and cosmetic products to blame? How do we restore a healthy balance of bacteria on eczema-prone skin? Is eczema a genetic disease or is that a myth? Learn more by listening to this provocative chat with Dr. Ian Myles, a cutting-edge researcher with the NIH who studies "microbiome transplants" for the treatment of eczema.
Research referenced in this podcast:
First in-human microbiome transplant using Roseomonas mucosa bacteria
Is allergy a disease of dysbiosis?
Episode 1: New ideas and ancient science -- A conversation with Dr. Peter Lio
Can you control itch with acupressure? Can toxins from bacteria complicate eczema? What is the Dr. Aron Regimen and what are we learning about it through research? Learn more in this interview with Dr. Peter Lio, a dermatologist and researcher with Northwestern University and the Chicago Integrative Eczema Center.
Research referenced in this podcast:
Acupressure Study
Review of alternative and complementary treatments for eczema
Case series study on CASM (Dr. Aron Regimen)
Review of the relationship between staph and eczema